![]() The incidence of hepatocellular carcinoma is highest in Asia and Africa, with an estimated half million new cases diagnosed per year globally, and more than 50% of whom are in China. Hepatocellular carcinoma (HCC) is one of the most common cancers and now it is the third leading cause of cancer deaths in worldwide. Therefore, we demonstrate that Akt/NF-κB pathway was involved in Annonaceous acetogenins reverses drug resistance of human hepatocellular carcinoma cells. ![]() We also found that there was a decreased activity of NF-κB and Akt in Annonaceous acetogenins treatment groups. ![]() We found that cell apoptosis was improved and cell cycle was arrested, further, multidrug-resistance proteins such as MDR1, MRP1, Topo-IIα, GST-π, cyclin D1, Survivin and bcl-2 are down-regulated, however, intracellular Rh-123 and caspase-3/8 was up-regulated by Annonaceous acetogenins treatment. In this study, we showed that annonaceous acetogenins is correlated with the drug resistance reversal in human hepatocellular carcinoma BEL-7402/5-FU and HepG2/ADM cell lines. ![]() ![]() Annonaceous acetogenins was a nature compound from Uvaria accuminata and it has show the anti-tumor proliferation activity in many types cancer. Hepatocellular carcinoma (HCC) is the most common tumor in worldwide and chemotherapy resistant is a severe obstacle in HCC treatment. ![]()
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